Police have issued an emergency declaration under the Public Safety Preservation Act (PSPA) due to a B-double carrying dangerous cargo which rolled-over on Fitzroy Development Rd, Valkyrie at around 5.20am today.
The truck driver received only minor injuries, said police.
The exclusion zone encompasses 3 kilometres around the crash site, including the airspace above.
Traffic is being diverted around the exclusion zone from Peak Downs Hwy and Golden Mile Road.
This incident is likely to last all day.
Members of the public are advised to avoid the area and urged to follow the advice of emergency services on the ground.
The Daily Mercury reports that a nearby school, which is outside the exclusion zone, has also been told to prepare to evacuate if needed.