Police and emergency services were called to the scene in the suburb of Emu Heights at about 10am on Sunday, September 21.
Police say their initial inquiries indicate the man was travelling north on Massy-Greene Drive in a Kenworth truck when he has collided with the rear of a second truck.
The driver of the second truck was transported to North West Regional Hospital by Ambulance Tasmania and was later discharged with no injuries.
The section of Massy Greene Drive between the Bass Highway and Old Surrey Road remained closed for several hours.
Anyone with information or relevant dash cam footage, is asked to contact police on 131 444. Information can be provided anonymously through Crime Stoppers Tasmania at crimestopperstas.com.au or on 1800 333 000.
“Our thoughts are with the man’s family and loved ones,” said police.
A report will be prepared for the coroner.